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bk channel currents  (Alomone Labs)


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    Alomone Labs bk channel currents
    Bk Channel Currents, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 95/100, based on 75 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bk+channels/pm40992632-57-0-18?v=Alomone+Labs
    Average 95 stars, based on 75 article reviews
    bk channel currents - by Bioz Stars, 2026-07
    95/100 stars

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    Figure 4. BK channels suppress L2/3 VIP-IN intrinsic excitability at high extracellular Ca2+ level A, examples of firing responses of type 1 upon a 500 ms-long pulse. Lower traces show step intensities of current injected to the soma, middle traces show neuronal firings at rheobase, upper traces represent maximum spike frequency in control ACSF (Ctrl, left) and after application of the BK channel antagonist (paxilline, Pax, right). B, mean (±SD) firing frequency–current curves type 1 in control and after Pax (P < 0.05, paired t test, n = 12). C, Hill sigmoidal curves fitted to the data shown in B, n = 12. D, left, within-cell comparison and mean (±SD) maximum firing frequency of type 1 in control and after Pax (P = 0.177, paired t test, n = 12). Right, same but for rheobase (P = 0.002, Wilcoxon test, n = 12). E–H, same as A–D but for pooled raw data of types 2 and 3 (type 2 + 3) (P = 0.820 Wilcoxon test and P < 0.001 paired t test, respectively, n = 10). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.

    Journal: The Journal of Physiology

    Article Title: Inhibition of BK channels by GABAb receptors enhances intrinsic excitability of layer 2/3 vasoactive intestinal polypeptide‐expressing interneurons in mouse neocortex

    doi: 10.1113/jp286439

    Figure Lengend Snippet: Figure 4. BK channels suppress L2/3 VIP-IN intrinsic excitability at high extracellular Ca2+ level A, examples of firing responses of type 1 upon a 500 ms-long pulse. Lower traces show step intensities of current injected to the soma, middle traces show neuronal firings at rheobase, upper traces represent maximum spike frequency in control ACSF (Ctrl, left) and after application of the BK channel antagonist (paxilline, Pax, right). B, mean (±SD) firing frequency–current curves type 1 in control and after Pax (P < 0.05, paired t test, n = 12). C, Hill sigmoidal curves fitted to the data shown in B, n = 12. D, left, within-cell comparison and mean (±SD) maximum firing frequency of type 1 in control and after Pax (P = 0.177, paired t test, n = 12). Right, same but for rheobase (P = 0.002, Wilcoxon test, n = 12). E–H, same as A–D but for pooled raw data of types 2 and 3 (type 2 + 3) (P = 0.820 Wilcoxon test and P < 0.001 paired t test, respectively, n = 10). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.

    Article Snippet: In vitro pharmacology Drugs used for the study were as follows: GABAbR agonist baclofen, 10 μM (Sigma-Aldrich, St Louis, MO, USA), NMDA receptor antagonist d-2-amino-5-phosphonovaleric acid (APV), 50 μM (Tocris Bioscience, UK), AMPA receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX), 20 μM (Tocris Bioscience, Bristol, UK), BK channel antagonist paxilline, 10 μM (Tocris Bioscience), GABAaR antagonist picrotoxin, 100 μM (Tocris Bioscience).

    Techniques: Injection, Control, Comparison

    Figure 6. Presynaptic GABAbRs increase L2/3 VIP-IN intrinsic excitability indirectly, through a reduction of GABAaR-mediated inhibition A, examples of firing responses of type 1 upon a 500 ms-long pulse. Lower traces show step intensities of current injected to the soma, middle traces show neuronal firings at rheobase, and upper traces represent maximum spike frequency in ACSF with the GABAaR blocker (picrotoxin, PTX) and BK channel antagonist paxilline (PTX + Pax, left)

    Journal: The Journal of Physiology

    Article Title: Inhibition of BK channels by GABAb receptors enhances intrinsic excitability of layer 2/3 vasoactive intestinal polypeptide‐expressing interneurons in mouse neocortex

    doi: 10.1113/jp286439

    Figure Lengend Snippet: Figure 6. Presynaptic GABAbRs increase L2/3 VIP-IN intrinsic excitability indirectly, through a reduction of GABAaR-mediated inhibition A, examples of firing responses of type 1 upon a 500 ms-long pulse. Lower traces show step intensities of current injected to the soma, middle traces show neuronal firings at rheobase, and upper traces represent maximum spike frequency in ACSF with the GABAaR blocker (picrotoxin, PTX) and BK channel antagonist paxilline (PTX + Pax, left)

    Article Snippet: In vitro pharmacology Drugs used for the study were as follows: GABAbR agonist baclofen, 10 μM (Sigma-Aldrich, St Louis, MO, USA), NMDA receptor antagonist d-2-amino-5-phosphonovaleric acid (APV), 50 μM (Tocris Bioscience, UK), AMPA receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX), 20 μM (Tocris Bioscience, Bristol, UK), BK channel antagonist paxilline, 10 μM (Tocris Bioscience), GABAaR antagonist picrotoxin, 100 μM (Tocris Bioscience).

    Techniques: Inhibition, Injection